John Barrymore

Dr. Henry Jekyll / Mr. Edward Hyde

Brandon Hurst

Sir George Carewe

Martha Mansfield

Millicent Carewe

Charles Lane

Dr. Richard Lanyon

Cecil Clovelly

Edward Enfield

Nita Naldi

Miss Gina

Louis Wolheim

Music Hall Proprietor

Alma Aiken

Extra (uncredited)

J. Malcolm Dunn

John Utterson (uncredited)

Ferdinand Gottschalk

Old Man at Table in Music Hall (uncredited)

Julia Hurley

Hyde's Landlady with Lamp (uncredited)

Jack McHugh

Street Kid - Raises Fist to Mr. Hyde (uncredited)

Georgie Drew Mendum

Patron in Music Hall (uncredited)

Blanche Ring

Woman at Table with Old Man in Music Hall (uncredited)

May Robson

Prostitute at Clinic (uncredited)

George Stevens

Jekyll's Butler Poole (uncredited)

Edgard Varèse

Policeman (uncredited)